Category Archives: We’re Really Fucked

More On Hacking The Vote

And I don’t mean hack in that positive lifehacking sense. I’ve written many times before about how, during the 2008 and 2012 elections, both in the general and Republican primary, there appears to be a pattern in multiple states, wherein … Continue reading

Posted in Voting, We're Really Fucked | 3 Comments

The Politics of Hopelessness

I’m tired of feeling like we’re losing even when we (sort of) win (boldface mine): Amid all the accusations that Hillary Clinton is not an honest or authentic politician, that she’s an endless shape-shifter who says whatever works to get … Continue reading

Posted in I For One Welcome Our Austerity Overlords, We're Really Fucked

The Unlovely Necessity of Public Health Spending

Public health efforts face a very difficult problem: they’re like car insurance. You hate paying it…until you get into an accident, then you’re really glad you have it. With that for prelude, we bring you this story about mosquito control–a … Continue reading

Posted in Insects, Public Health, Viruses, We're Really Fucked | 4 Comments

Colistin Resistance Is Now Linked to Carbapenem Resistance: We Failed

For those just tuning in, a little over a month ago, the microbiology and public health world was rocked by the discovery of plasmid-borne colistin resistance: First, some background: polymyxins, including polymyxin E also known as colistin, are the last … Continue reading

Posted in Antibiotics, E. coli, Plasmids, Public Health, We're Really Fucked | 5 Comments

Our Long-Term Crisis Isn’t the Gentrified City But the Unsustainable Suburb

Something that’s lurking in the background of the U.S. economy, and which will erupt with a fury in ten years or so is the need to replace suburban infrastructure: underground wires, pipes, and so on. This is something new that … Continue reading

Posted in Housing, Transportation, We're Really Fucked | 1 Comment

Plasmid-Borne Colistin Resistance Has Jumped Species and Maybe Hemispheres

Friday, I described the discovery of the gene mcr-1, which is a transmissible colistin resistance gene found on a bacterial plasmid (a plasmid is a mini-chromosome that can move from bacterium to bacterium). This is really bad news, since colistin … Continue reading

Posted in Antibiotics, E. coli, Plasmids, Salmonella, We're Really Fucked | 3 Comments

Last Line of Antimicrobial Defense Is Falling: Colistin Resistance Transmission

Actually, it’s sort of reached the rout stage. From China (don’t worry, I’ll translate from Science into English; boldface mine): Background: Until now, polymyxin resistance has involved chromosomal mutations but has never been reported via horizontal gene transfer. During a … Continue reading

Posted in Antibiotics, E. coli, Plasmids, We're Really Fucked | 9 Comments