Category Archives: Antibiotics

The Second Worst Cost Of Antibiotic Resistance

Of course, the first is the illness and death that results from untreatable infections. But Bill Hanage makes a very important point (boldface mine): Although the risk of getting a completely resistant infection is low in the United States, about … Continue reading

Posted in Antibiotics

The Clinical And Bioinformatic CTX-M Problem

We’ll get to what CTX-M is in a bit, but first some biology background. Let’s talk about some game theory carbapenem antibiotics (also referred to as carbapenems): Before we get started, let’s do a quick biology review. A serious health … Continue reading

Posted in Antibiotics, Genomics, KPC

We Don’t Know How Much Resistance Many Antibiotic Resistance Genes Actually Provide

This is a problem. At the recent ASM 2017 Microbe meeting (the annual meeting for the American Society for Microbiology), there were many groups, academic, governmental, and industry, trying to use bacterial genomic sequence to predict which antibiotics would be … Continue reading

Posted in Antibiotics, KPC

Maybe We Need To Remind Patients That Antibiotics Are Chemotherapy

After all, two of the leading journals about antibiotic resistance do have chemotherapy in the title. One reason, I think, many people who try to get antibiotics from their doctors for problems that don’t call for an antibiotic is the … Continue reading

Posted in Antibiotics

What We Mean By ‘Antibiotic Resistance’: The Ciprofloxacin-Shigella Alert Edition

While the problem of antibiotic resistance is a common topic (and not just on this blog!), there is little discussion of how we actually measure it–and those details do matter. So before we get to a recent CDC alert–one all … Continue reading

Posted in Antibiotics, CDC, E. coli

UTIs: The Other Part Of Antibiotic Resistance That Should Worry Us

I’ve written frequently about the danger CREs–carbapenem-resistant enterobacteriaceae–pose. To recap, CREs are E. coli and its relatives that are resistant to all* penicillin-related drugs (those that start with ceph- or cef-, or end with -cillin or -penem). The bad news … Continue reading

Posted in Antibiotics, E. coli | 1 Comment

Pleiotropy Might Help Slow The Evolution Of Antibiotic Resistance

Well, there’s a silver lining in a recently-discovered dark cloud. Before we get started, let’s do a quick biology review. A serious health problem are carbapenem-resistant enterobacteriaceae (‘CRE’)–E. coli and relatives that are resistant to all antibiotics that start with … Continue reading

Posted in Antibiotics, KPC