Category Archives: Antibiotics

Good News On The Antibiotic Development Front?

A while ago, I mentioned a serious problem in the attempt to combat drug resistance: …I think the greatest challenge is medicinal chemistry. By way of prelude, in days of yore, before the FDA approved virtually everything it was sent, … Continue reading

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Five Percent of D.C.’s Enterobacterial Isolates Are CRE?

I’ve discussed before how difficult it is to measure the frequency of CRE (carbapenem-resistant enterobacteriaceae–E. coli and relatives that are usually resistant to all treatment, with the possible exception of colistin). This is, in part, due to a ‘denominator problem’: … Continue reading

Posted in Antibiotics, DC, KPC

Do Drug Companies Need Financial Incentives For Antibiotic Development?

One of the commonly stated problems that limits the development of new antibiotics is that the economic incentives are all wrong. A company has to spend a lot of money developing a drug that we then have an incentive not … Continue reading

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Data Reporting Doubts About The Antibiotic Resistance Atlas

Last week, I provided some links to the CDC’s Antibiotic Resistance Patient Safety Atlas (there’s an interactive version here). First, the CDC should be given kudos for putting this resource together. This isn’t a criticism of their effort. But the … Continue reading

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An Atlas Of Antibiotic Resistance

So the CDC released an Antibiotic Resistance Patient Safety Atlas. Details are here, while the interactive site is here. A good introduction can be found here. I didn’t realize D.C. had such a high percentage of CRE infections. By the … Continue reading

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And Now Italy

Italy has joined the plasmid-borne colistin resistance club (colistin is the last line of defense against carbapenem-resistant enterobacteriaceae–’CRE’–except when it doesn’t work). From ProMED (boldface mine): The mcr-1 gene, which encodes transferable resistance to colistin, has been confirmed in commensal … Continue reading

Posted in Antibiotics

What Does the End of Antibiotic Era Mean?

Obviously, nothing good. Yet we often hear that the era of antibiotics is nearing its end (I might have even used that phrase). So what does the end of the antibiotic era mean? I don’t think we will have to … Continue reading

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