Category Archives: Antibiotics

Thoughts On A Completely Drug Resistant Klebsiella

Since I’ve been asked about this, I’ll have some comments in a bit, but first, the CDC report (boldface mine): On August 25, 2016, the Washoe County Health District in Reno, Nevada, was notified of a patient at an acute … Continue reading

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A Failure Of Data Transmission: The CRE Edition

There’s a very interesting article that came out recently describing the first public report of carbapenem resistance in E. coli from the U.S. food supply. Maryn McKenna provides a good overview: Bacteria containing a gene that confers resistance to a … Continue reading

Posted in Antibiotics, Data Stuff, Genomics | 1 Comment

Man’s–And Clostridium difficile’s–Best Friend

This is disturbing (boldface mine; added line breaks for clarity): Nosocomial acquisition of Clostridium difficile is well documented, yet recent studies have highlighted the importance of community acquired infections and identified community associated reservoirs for this pathogen. Multiple studies have … Continue reading

Posted in Antibiotics, Public Health | 2 Comments

MCR-1 Confers Resistance To Lysozyme, Part Of Our Immune System

If you don’t know what pleiotropy means, you had better learn the word: when one mutational change confers multiple phenotypic effects. When it comes to antibiotic resistance, this is a bad thing–for us, anyway. Which brings us to mcr-1, the … Continue reading

Posted in Antibiotics, We're Really Fucked

It Sucks To Be This Patient: The Seven CPO Edition

It really does for this New Zealand (‘NZ’) patient (boldface mine): Here, we report the isolation of seven distinct CPO [carbapenemase producing organisms–resistant to the last line beta-lactam antibiotics], together with an ESBL-producing Pseudomonas aeruginosa and Proteus mirabilis with an … Continue reading

Posted in Antibiotics, KPC, NDM-1, Plasmids, Public Health, We're Really Fucked

Bacterial Whole Genome Sequencing And The Clinic: The Future Is Almost Here

I heard this talk almost a year ago*, so I’m glad this paper is finally out (I’ll translate into English below; boldface mine): The increasing prevalence of multidrug-resistant (MDR) bacteria is a serious global challenge. Here, we studied prospectively whether … Continue reading

Posted in Antibiotics, E. coli, Genomics, KPC, MRSA, NDM-1, Public Health | 1 Comment

Good News On The Antibiotic Development Front?

A while ago, I mentioned a serious problem in the attempt to combat drug resistance: …I think the greatest challenge is medicinal chemistry. By way of prelude, in days of yore, before the FDA approved virtually everything it was sent, … Continue reading

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