Category Archives: Antibiotics

What We Mean By ‘Antibiotic Resistance’: The Ciprofloxacin-Shigella Alert Edition

While the problem of antibiotic resistance is a common topic (and not just on this blog!), there is little discussion of how we actually measure it–and those details do matter. So before we get to a recent CDC alert–one all … Continue reading

Posted in Antibiotics, CDC, E. coli

UTIs: The Other Part Of Antibiotic Resistance That Should Worry Us

I’ve written frequently about the danger CREs–carbapenem-resistant enterobacteriaceae–pose. To recap, CREs are E. coli and its relatives that are resistant to all* penicillin-related drugs (those that start with ceph- or cef-, or end with -cillin or -penem). The bad news … Continue reading

Posted in Antibiotics, E. coli | 1 Comment

Pleiotropy Might Help Slow The Evolution Of Antibiotic Resistance

Well, there’s a silver lining in a recently-discovered dark cloud. Before we get started, let’s do a quick biology review. A serious health problem are carbapenem-resistant enterobacteriaceae (‘CRE’)–E. coli and relatives that are resistant to all antibiotics that start with … Continue reading

Posted in Antibiotics, KPC

Thoughts On A Completely Drug Resistant Klebsiella

Since I’ve been asked about this, I’ll have some comments in a bit, but first, the CDC report (boldface mine): On August 25, 2016, the Washoe County Health District in Reno, Nevada, was notified of a patient at an acute … Continue reading

Posted in Antibiotics | 1 Comment

A Failure Of Data Transmission: The CRE Edition

There’s a very interesting article that came out recently describing the first public report of carbapenem resistance in E. coli from the U.S. food supply. Maryn McKenna provides a good overview: Bacteria containing a gene that confers resistance to a … Continue reading

Posted in Antibiotics, Data Stuff, Genomics | 1 Comment

Man’s–And Clostridium difficile’s–Best Friend

This is disturbing (boldface mine; added line breaks for clarity): Nosocomial acquisition of Clostridium difficile is well documented, yet recent studies have highlighted the importance of community acquired infections and identified community associated reservoirs for this pathogen. Multiple studies have … Continue reading

Posted in Antibiotics, Public Health | 2 Comments

MCR-1 Confers Resistance To Lysozyme, Part Of Our Immune System

If you don’t know what pleiotropy means, you had better learn the word: when one mutational change confers multiple phenotypic effects. When it comes to antibiotic resistance, this is a bad thing–for us, anyway. Which brings us to mcr-1, the … Continue reading

Posted in Antibiotics, We're Really Fucked