Category Archives: KPC

We Don’t Know How Much Resistance Many Antibiotic Resistance Genes Actually Provide

This is a problem. At the recent ASM 2017 Microbe meeting (the annual meeting for the American Society for Microbiology), there were many groups, academic, governmental, and industry, trying to use bacterial genomic sequence to predict which antibiotics would be … Continue reading

Posted in Antibiotics, KPC | Leave a comment

Pleiotropy Might Help Slow The Evolution Of Antibiotic Resistance

Well, there’s a silver lining in a recently-discovered dark cloud. Before we get started, let’s do a quick biology review. A serious health problem are carbapenem-resistant enterobacteriaceae (‘CRE’)–E. coli and relatives that are resistant to all antibiotics that start with … Continue reading

Posted in Antibiotics, KPC

Resistant Bacteria, Possibly Much Deadlier Than We Thought

Or as we often say around here, you have to understand the limitations of your data–in this case, hospital records (boldface mine): Sharley McMullen of Manhattan Beach came down with a fever just hours after being wheeled out of a … Continue reading

Posted in KPC, Public Health

It Sucks To Be This Patient: The Seven CPO Edition

It really does for this New Zealand (‘NZ’) patient (boldface mine): Here, we report the isolation of seven distinct CPO [carbapenemase producing organisms–resistant to the last line beta-lactam antibiotics], together with an ESBL-producing Pseudomonas aeruginosa and Proteus mirabilis with an … Continue reading

Posted in Antibiotics, KPC, NDM-1, Plasmids, Public Health, We're Really Fucked

Bacterial Whole Genome Sequencing And The Clinic: The Future Is Almost Here

I heard this talk almost a year ago*, so I’m glad this paper is finally out (I’ll translate into English below; boldface mine): The increasing prevalence of multidrug-resistant (MDR) bacteria is a serious global challenge. Here, we studied prospectively whether … Continue reading

Posted in Antibiotics, E. coli, Genomics, KPC, MRSA, NDM-1, Public Health | 1 Comment

Five Percent of D.C.’s Enterobacterial Isolates Are CRE?

I’ve discussed before how difficult it is to measure the frequency of CRE (carbapenem-resistant enterobacteriaceae–E. coli and relatives that are usually resistant to all treatment, with the possible exception of colistin). This is, in part, due to a ‘denominator problem’: … Continue reading

Posted in Antibiotics, DC, KPC

So Let’s Say We Find a ‘Superbug’ In the Food Supply…

…now what? When I’m not blogging or fighting crime, one of the things I do is worry (along with some science!) about the spread of antibiotic resistance. The U.S. government has several programs that monitor the spread of antibiotic resistance, … Continue reading

Posted in Antibiotics, Food, KPC, NDM-1, Public Health