Man’s–And Clostridium difficile’s–Best Friend

This is disturbing (boldface mine; added line breaks for clarity):

Nosocomial acquisition of Clostridium difficile is well documented, yet recent studies have highlighted the importance of community acquired infections and identified community associated reservoirs for this pathogen. Multiple studies have implicated companion pets and farm animals as possible sources of community acquired C. difficile infections in humans. To explore the potential role of pet dogs in human C. difficile infections we systematically collected canine fecal samples (n = 197) in Flagstaff, AZ. Additionally, nineteen fecal samples were collected at a local veterinary clinic from diarrheic dogs.

We used these combined samples to investigate important questions regarding C. difficile colonization in pet canines: 1) What is the prevalence and diversity of C. difficile in this companion pet population, and 2) Do C. difficile isolates collected from canines genetically overlap with isolates that cause disease in humans?

We used a two-step sequence typing approach, including multilocus sequence typing to determine the overall genetic diversity of C. difficile present in Flagstaff canines, and whole-genome sequencing to assess the fine-scale diversity patterns within identical multilocus sequence types from isolates obtained within and among multiple canine hosts.

We detected C. difficile in 17% of the canine fecal samples with 10% containing toxigenic strains that are known to cause human disease. Sequencing analyses revealed similar genotypes in dogs and humans. These findings suggest that companion pets are a potential source of community acquired C. difficile infections in humans.

Looks like the renaming of Clostridium difficile to Clostridioides diffcile hasn’t caught on yet. But I digress.

One in six canine isolates had C. difficilewhich kills around 29,000 patients per year in the U.S. and can also cause permanent life-changing illness. More disturbing is that one in ten isolates produced known toxins that can cause disease (and kill). A couple more studies are probably needed though in other locations to determine if this result holds.

Among immunocompromised patients as well as high-risk for hospitalization people (e.g., elderly), we might have to start thinking about dogs as a risk factor for C. difficile infection. Which is kind of depressing.

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2 Responses to Man’s–And Clostridium difficile’s–Best Friend

  1. Michael J Lauer says:

    Hypothesis: Dogs are being exposed by eating out the household trash can where various uncooked sources of the infection are found.

  2. noddin0ff says:

    what happened to Peptoclostridium difficile?

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