NIH Director Francis Collins makes my head explody (boldface mine):
Instead, a complex array of other factors seems to have contributed to the lack of reproducibility…
Exacerbating this situation are the policies and attitudes of funding agencies, academic centres and scientific publishers. Funding agencies often uncritically encourage the overvaluation of research published in high-profile journals. Some academic centres also provide incentives for publications in such journals, including promotion and tenure, and in extreme circumstances, cash rewards.
Collins not only has agency in this situation, he literally runs one (or twenty-seven, depending on how you want to look at it). Maybe he could do something about this problem?