Category Archives: We’re Really Fucked

Colistin Resistance Is Now Linked to Carbapenem Resistance: We Failed

For those just tuning in, a little over a month ago, the microbiology and public health world was rocked by the discovery of plasmid-borne colistin resistance: First, some background: polymyxins, including polymyxin E also known as colistin, are the last … Continue reading

Posted in Antibiotics, E. coli, Plasmids, Public Health, We're Really Fucked | 5 Comments

Our Long-Term Crisis Isn’t the Gentrified City But the Unsustainable Suburb

Something that’s lurking in the background of the U.S. economy, and which will erupt with a fury in ten years or so is the need to replace suburban infrastructure: underground wires, pipes, and so on. This is something new that … Continue reading

Posted in Housing, Transportation, We're Really Fucked | 1 Comment

Plasmid-Borne Colistin Resistance Has Jumped Species and Maybe Hemispheres

Friday, I described the discovery of the gene mcr-1, which is a transmissible colistin resistance gene found on a bacterial plasmid (a plasmid is a mini-chromosome that can move from bacterium to bacterium). This is really bad news, since colistin … Continue reading

Posted in Antibiotics, E. coli, Plasmids, Salmonella, We're Really Fucked | 3 Comments

Last Line of Antimicrobial Defense Is Falling: Colistin Resistance Transmission

Actually, it’s sort of reached the rout stage. From China (don’t worry, I’ll translate from Science into English; boldface mine): Background: Until now, polymyxin resistance has involved chromosomal mutations but has never been reported via horizontal gene transfer. During a … Continue reading

Posted in Antibiotics, E. coli, Plasmids, We're Really Fucked | 9 Comments

Block Off All the Roads to Maryland. Do It Now

This will not help reduce traffic problems in D.C. (boldface mine): On Tuesday, the MVA announced that parallel parking is no longer part of the driver’s license test in Maryland. Officials said other parts of the test — the two-point … Continue reading

Posted in DC, Fucking Morons, Run Ya Bastids!, Transportation, We're Really Fucked | 2 Comments

Failure Is An Option: Antibiotic Resistance and Global Warming

A while ago, I argued that many of our supposedly ‘scientific’ or technological problems aren’t anything of the sort: instead, they are largely political failures. Consider the problem of antibiotic resistance: There are a lot of things we could currently … Continue reading

Posted in Antibiotics, Global Warming, We're Really Fucked | 8 Comments

Remember When I Wrote That Some Antibiotic Resistance Is Annoying But Not Catastrophic?

Well, I also mentioned that sometimes antibiotic resistance is catastrophic. By way of Scary Disease Woman (aka ‘Maryn McKenna’), here ya go (boldface mine): To investigate the antibacterial resistance to doripenem in China and to understand the distribution trends of … Continue reading

Posted in Antibiotics, We're Really Fucked